What is Pure Nutrition Super Omega-3 Fish Oil 400 EPA/300 DHA?
Pure Nutrition USA Omega-3 Fish Oil 400 EPA/300 DHA is a highly-absorbable and concentrated fish oil supplement containing evidence-based doses of the key omega-3 essential fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). A multitude of clinical studies demonstrate that EPA and DHA are crucial for promoting healthy cardiovascular function, enhancing skin tissue, supporting joints, boosting immunity, and more.1,2
Why Should I Use Pure Nutrition Super Omega-3 Fish Oil 400 EPA/300 DHA?
The major providers of EPA and DHA in the human diet are freshwater fish. However, eating fish is becoming more of a health concern due to noxious heavy metals and environmental toxins that accumulate in marine food sources. For simplicity and practicality, many people use a fish oil supplement to meet their daily EPA and DHA requirements without having to worry about eating fish.
Omega-3 essential fatty acids are also present in foods almonds, flax seed, and oats, but the amount is minimal. As such, it’s to your benefit to use a fish oil supplement even if you eat a diet rich in foods that contain omega-3 fatty acids.
How Pure Nutrition USA Super Omega-3 Fish Oil 400 EPA/300 DHA Works
Omega-3 supplements contain a key polyunsaturated fatty acids that are necessary for optimal wellness and longevity. In other words, you must consume omega-3 essential fatty acids since the human body doesn’t create them internally.
There are three types of Omega-3 fatty acids, but two of them in particular are crucial for optimum health—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Alpha-linolenic acid (ALA) is another essential omega-3 that is found in many land plants, but it plays a lesser roles in humans. Your body can also convert small amounts of ALA to DHA.
Furthermore, there are many other omega-3 fatty acids that are required for proper longevity and well-being, but EPA and DHA remain the most beneficial according to clinical research.3,4
EPA and DHA are found in many parts of the human body, particularly the membranes of cells, making them integral components of our physiology. DHA and EPA are also necessary precursors of several disease-preventing metabolites.4
Consistently using a fish oil supplement leads to EPA and DHA enriching your blood lipids, cells and tissues, which has a variety of benefits for enhancing your health and decreasing the risk of many diseases.1
What Makes Pure Nutrition USA Super Omega-3 Fish Oil 400 EPA/300 DHA better than other Fish Oil Supplements?
Fish oil and omega-3 supplements are quite popular and have been for decades. However, not all omega-3 fish oil supplements are the same. Choosing the right omega-3 fish oil supplement will make or break your results.
Many omega-3 fish oil products provide a seemingly large content of fish oil, but the oil is poor quality and has minimal concentrations of EPA and DHA (this makes the product ineffective and rather worthless).
Pure Nutrition USA offers two Omega-3 Fish Oil supplements with research-based doses of EPA and DHA:
Omega-3 Fish Oil 400 EPA/300 DHA, which is highly concentrated and provides a 2:1 ratio of EPA:DHA
Omega-3 Fish Oil 400 EPA/300 DHA, which provides a 3:2 ratio of EPA:DHA.
Always keep in mind that the amount of DHA and EPA you ingest is ultimately what will determine the results you experience from using a fish oil supplement. Pure Nutrition USA Omega-3 Fish Oil 480 EPA/240 DHA is also free from impurities and resists oxidation.
Pure Nutrition USA Omega-3 Fish Oil 400 EPA/300 DHA Benefits
Benefits of EPA and DHA found in Pure Nutrition Super Omega-3 Fish Oil 400 EPA/300 DHA include:3,4
- Highly concentrated source of EPA and DHA
- Promote healthy cardiovascular function
- Boost immunity
- Improve brain health and cognition
- Support healthy skin tissue
- Support proper hormone signaling
- Bolster energy production
- Enhance joint integrity and function
Read below to learn more about the research behind omega-3 fish oil supplements.
Promote Cardiovascular Function
One of the most therapeutic benefits of using an omega-3 supplement is enhancing your cardiovascular function. Studies consistently show that DHA and EPA are some of the strongest regulators of blood pressure, cholesterol/blood lipids, and inflammatory markers (which are all used as risk factors for things like heart disease).5
EPA and DHA from a fish oil supplement work to decrease total cholesterol, LDL (“bad”) cholesterol, and inflammation associated with substances like C-reactive protein. In fact, clinical research has shown that patients taking a fish oil supplement produced upwards of 70% less C-reactive protein than those who didn’t supplement with fish oil.6
Brain Health & Cognitive Function
Fish oil has been shown to drastically improve mental state exam scores in patients with cognitive dysfunction.7 DHA and EPA are both components of neuron membrane phospholipids meaning a proper fish oil supplement will help boost nervous system function and decrease age-related neurodegenerative processes.
Omega-3 fish oil supplements help reduce production of lipopolysaccharide (LPS)-induced proinflammatory cytokines, which is essential for controlling systemic inflammatory response. In fact, a human study showed that fish oil use decreased cytokines by more than 50% compared to placebo.8
Improve Skin Health & Reduce Acne
The DHA and EPA in fish oil are postulated to be the primary anti-inflammatory nutrients for skin tissue.9 Research shows that regular use of a fish oil supplement reduces signaling cascades induced by pro-inflammatory chemicals in the skin, such as leukotriene B4 (LTB4) and prostaglandin E2 (PGE2).10 DHA and EPA also appear to control oxidative stress in skin tissue by neutralizing free radicals.11
Moreover, a 3-month clinical study of 13 individuals with “severe” acne revealed that fish oil supplementation decreased the acne to “mild” levels in eight subjects.12 In fact, another study (comprising more than 1000 adolescents) showed that higher consumption of EPA and DHA from fish was correlated with reduced signs of acne and oily skin.13
Enhance Joint Function and Integrity
As your joints are exposed to biomechanical and physiological stress through things like working out, your body naturally increases cytokine production (which can lead to pain and inflammation). Research suggests that omega-3 fish oil supplements help block the actions of proinflammatory markers in joint regions, such as tumor necrosis factor alpha and interleukin-6.14
How Much Fish Oil Should I Be Getting?
Research recommends that a combined intake of EPA+DHA in the range of 1000-3000 mg per day (with a 2:1 or 3:2 ratio of EPA:DHA) is sufficient for health and longevity purposes.15 This comes out to about two servings of Pure Nutrition USA Omega-3 Fish Oil 400 EPA/300 DHA daily.
Pure Nutrition USA also offers Omega-3 Fish Oil with 180 EPA/120 DHA if you prefer to take in a 3:2 ratio of EPA:DHA.
1. Janice K. Kiecolt-Glaser, Martha A. Belury, Rebecca Andridge, William B. Malarkey, Ronald Glaser. Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial. Brain, Behavior, and Immunity, 2011; DOI:
2. Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2003). Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arteriosclerosis, thrombosis, and vascular biology, 23(2), e20-e30.
3. Ruxton, C. H. S., Reed, S. C., Simpson, M. J. A., & Millington, K. J. (2004). The health benefits of omega‐3 polyunsaturated fatty acids: a review of the evidence. Journal of Human Nutrition and Dietetics, 17(5), 449-459.
4. Swanson, D., Block, R., & Mousa, S. A. (2012). Omega-3 fatty acids EPA and DHA: health benefits throughout life. Advances in Nutrition: An International Review Journal, 3(1), 1-7.
5. Kelley, D. S., Siegel, D., Fedor, D. M., Adkins, Y., & Mackey, B. E. (2009). DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men. The Journal of nutrition, 139(3), 495-501.
6. Ebrahimi, M., Ghayour-Mobarhan, M., Rezaiean, S., Hoseini, M., Parizade, S. M. R., Farhoudi, F., ... & Shakeri, M. T. (2009). Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta cardiologica, 64(3), 321-327.
7. Kidd, P. M. (2007). Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Alternative medicine review, 12(3), 207.
8. Liao, Z., Dong, J., Wu, W., Yang, T., Wang, T., Guo, L., ... & Wen, F. (2012). Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. Respiratory research, 13(1), 110.
9. Danno, K., Ikai, K., & Imamura, S. (1993). Anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models. Archives of dermatological research, 285(7), 432-435.
10. Boelsma, E., Hendriks, H. F., & Roza, L. (2001). Nutritional skin care: health effects of micronutrients and fatty acids–. The American journal of clinical nutrition, 73(5), 853-864.
11. Zouboulis C, Saborowski A, Boschnakow A: Zileuton, an oral 5-lipoxygenase inhibitor, directly reduces sebum production. Dermatology. 2005, 210: 36-8. 10.1159/000081481
12. Khayef, G., Young, J., Burns-Whitmore, B., & Spalding, T. (2012). Effects of fish oil supplementation on inflammatory acne. Lipids in health and disease, 11(1), 165.
13. Hitch JM, Greenburg BG: Adolescent acne and dietary iodine. Arch Dermatol. 1961, 84: 898-911.
14. Kremer, J. M., Lawrence, D. A., Petrillo, G. F., Litts, L. L., Mullaly, P. M., Rynes, R. I., ... & Bigaouette, J. (1995). Effects of high‐dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs clinical and immune correlates. Arthritis & Rheumatism, 38(8), 1107-1114.
15. Kris-Etherton, P. M., Grieger, J. A., & Etherton, T. D. (2009). Dietary reference intakes for DHA and EPA. Prostaglandins, Leukotrienes and Essential Fatty Acids, 81(2), 99-104.